CPTAC

The National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is a national effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome and genome analysis, or proteo-genomics.

The CPTAC seeks to perform deep-scale proteogenomics profiling across multiple cancer types, including breast invasive carcinoma, lung adenocarcinoma, ovarian serous cystadenocarcinoma and others.

Proteogenomics is an approach to tumor profiling that combines next-generation DNA and RNA sequencing with mass spectrometry-based proteomics to provide deep, unbiased quantification of proteins and post-translational modifications such as phosphorylation.